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Acknowledgements This work was funded by the DFG grant DE 1431/20-1 to M.D

In addition, the integration of pharmacokineticpharmacodynamic correlation studies, particularly in translational models, will be essential to substantiate therapeutic efficacy

10.3390/biology10111165 66 Tsuru-AoyagiK.PottsM

Moreover, H 2 O 2 /O/OH modulate metabolic pathways, such as the tricarboxylic acid cycle and mitochondrial function, thereby indirectly influencing the availability of essential metabolites required for epigenetic enzyme modifications [164]