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The 2-Week Rule A helpful guideline many clinicians use is this: If a side effect appears for the first time after two weeks of stable treatment, or worsens significantly after the initial adjustment period, it deserves provider evaluation

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investigated serum GABA, glutamate (Glu), and the GABA/Glu ratio in children with ASD and found that plasma GABA, Glu, and the GABA/Glu ratio were significantly elevated in children with ASD (120)