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10.1016/j.jep.2021.114132 62 GhasemzadehA.JaafarH

Due to their extraordinary nature, these small molecules can help prevent cancerous cells from forming as it induces apoptosis of various cancer cell lines and has potent antiinflammatory activity by inhibiting a pathway resulting in NF-B activation (Arango et al., 2013)

However, the most important advantage is the very safe profile of BPC (the lethal dose (LD1) could be not achieved) (Seiwerth et al., 2018), emphasized in terms of its physiological role (assessed using in situ hybridization and immunostaining for BPC 157 in the human gastrointestinal mucosa, lung bronchial epithelium, the epidermal layer of the skin, and kidney glomeruli) (Seiwerth et al., 2018)

Mechanism BPC-157 interacts with EGR-1 and VEGF, promoting the development of new blood vessels or angiogenesis