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Phase 1b/2 study of binimetinib (BINI) in combination with nivolumab (NIVO) or NIVO plus ipilimumab (IPI) in patients (pts) with previously treated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) with RAS mutation

This approach isolates each compound's contribution and ensures any adverse interactions are detected before full-dose stacking

Therefore, exploring the involvement of mitochondria in AP is crucial for understanding the disease mechanism and identifying potential therapeutic targets

Wallerian degeneration is executed by an NMN-SARM1-dependent late Ca(2+) influx but only modestly influenced by mitochondria