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349 Meanwhile, RA patients typically have lower antioxidants, such as GSH and GSH peroxidase, and treatment with methotrexate significantly changes oxidative stress indicators in RA patients

While antioxidant and anti-inflammatory strategies show considerable promise, several important limitations must be acknowledged

In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

Sometimes a deficiency causes neurological symptoms, such as numbness in the hands and feet, confusion, or trouble speaking or walking