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This depends on your goals: For skin brightening: 12 sessions per week for 46 weeks, then maintenance For general wellness or detox: Once weekly or biweekly For chronic fatigue or oxidative stress: Customized protocols are recommended Some people notice increased energy and mental clarity within hours

This, in turn, can sustain CSC self-renewal while limiting oxidative stress and preserving mitochondrial function [55,56,57]

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We then evaluated fatty acid composition by GC-MS and separated the four groups by principal component analysis (PCA) (Fig