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According to the article, COVID-19 infections begin at the ACE2 receptor, which is a protein on the surface of cells throughout the body, including the upper and lower respiratory tracks

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They also revealed the combination of favipiravir (antiviral therapeutic for SARS-CoV-2) with nicotine could successfully block 6LZG, a main active site of ACE2-S protein, suggesting the potential influence of this combination for blocking ACE2 versus SARS-CoV-2 [334]