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This finding implies the physiological importance of OTUD5 in regulating the stability of associating proteins

Reactive astrocytes, in response to oxidative stress, alter the expression of key enzymes such as nitric oxide synthase (NOS), NADPH oxidase (NOX) enzymes and fatty acid amide hydrolase, which, in turn, enhance the production of oxidative agents 93

Recent animal- and human-based studies described the enhanced percentage of eryptotic erythrocytes in patients with hepatic failure and hyperbilirubinemia [210, 250, 280, 283, 284]

18 Two otherwise healthy blood donors may produce RBC units of vastly different storage quality as a consequence of recent dietary intake, medications, or occupational exposures