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They have discovered that polyphenols may exhibit the ability to scavenge free radicals through (1) direct reaction with reactive oxygen species (ROS), (2) enhanced dismutation of free radicals to compounds with much lower reactivity, (3) inhibition of catalase enzyme activity, (4) increased activity of antioxidant enzymes such as SOD, (5) chelation with pro-oxidative metals like iron and copper, and (6) increasing the effectiveness of other small antioxidants like tocopherols and ascorbic acid [208, 209]
Korman NJ, Passeron T, Okubo Y, Bagel J, Warren RB, Spelman L, Winthrop K, Hoyt K, Scharnitz T, Banerjee S (2024) Deucravacitinib in plaque psoriasis: laboratory parameters through 4 years of treatment in the phase 3 POETYK PSO-1, PSO-2, and LTE trials
And the drug carrier exhibits higher drug loading capacity, minimizing the systemic spread of toxicity during circulation by binding to pH-sensitive drug release
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