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10.1016/S0014-5793(99)01402-7 FEBS Lett

Furthermore, GSH depletion compromises mitochondrial function, sensitizes cells to toxicants worsening drug-induced hepatotoxicity [61]

The concern surrounding Gilberts syndrome and paracetamol is based on the putative theory that a reduction in the glucuronidation of paracetamol leaves a greater fraction of the drug available to be oxidised, potentially causing toxicity

In addition to environmental factors including smoking, air pollution, infections, and radiation exposure, maternal factors including nutrition, lifestyle, mental health, and antibiotic use can influence the development of the fetus and the health of the expectant mother