We have a lead compound that we really want to explore, because it does, in fact, interact with a viral protein in the way that we predicted it to interact, so it has a chance of inhibiting viral entry into a host cell, says Brad Pentelute, an MIT associate professor of chemistry, who is leading the research team
The mechanism of actions in medical plants is broad, including regulating intestinal microbiota and permeability, upregulating both mRNA and protein expressions of claudin-1, lowering extracellular signal-regulated kinase activation in hepatocytes, suppressing MLCK-MLC phosphorylation signaling pathway, and protecting on IECs against LPS-insult [198]
doi: 10.1016/j.jacc.2006.11.039 64
Dehydroascorbate reductase (DHAR) DHAR (M.C.1.8.5.1) reduces dehydroascorbate (DHA) to AA using Reduced Glutathione (GSH) as an electron donor (Eltayeb et al., Glutathione reductase (GR) GR (E.C.1.6.4.2) is a flavoprotein oxidoreductase which uses NADPH as a reductant to reduce GSSG to GSH
