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By comparison of the total amount of excreted nicotine with the total amount of nicotine in the pinch per time unit, it has been concluded that only 10-20 % of the nicotine originally present in the pinch is absorbed via the buccal mucosa and reaches the systemic circulation (Andersson et al., 1994

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Some brands explored subjects of chemistry and biology, and others even had healthy maxims on them, such as Keep Fit, and Safety First. The Boys and Girls Scouts even had cigarette cards made for their associations