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In another example, trigonelline, a coffee-derived alkaloid, also lowers Nrf2 levels in drug-resistant pancreatic cancer cell lines by blocking Nrf2-dependent proteasomal gene expression of s5a/psmd4 and a5/psma5 and reducing proteasome activities

In addition to UV exposure, other lifestyle factors contribute to going gray, like smoking, anemia, poor nutrition, low B vitamins, and untreated thyroid conditions, says Hadley King, MD, a dermatologist based in New York City

Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet cell

[DOI] [PubMed] [Google Scholar] 31.Koutlas IG