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Moreover, age of smoking ( = 0.16, P = 0.21), cigarettes per day ( = 0.08, P = 0.05), smoking cessation ( = 0.06, P = 0.18), smoking initiation ( = 0.01, P = 0.61), and alcohol consumption ( = 0.08, P = 0.20) indicated no significant association with the metabolic ratio of clozapine and norclozapine concentration (Supplementary Table 8)