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Since there is no absolute consensus on the use of these terms in the literature, in this review, we define immunogenicity as the ability of an mRNA therapeutic to trigger a target-specific humoral immune response, and reactogenicity as the activation of intracellular innate immune sensing systems

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SLAs with different types and activities were effective across juvenile species, including children [62] and juvenile mammalian animals [9], suggesting their potential targeting of conserved microbiota in the intestinal tract

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