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Glutamine contains an -amino group which is in the protonated NH 3 + form under biological conditions and a carboxylic acid group which is in the deprotonated COO form, known as carboxylate, under physiological conditions

Orexin deficiency is notably associated with narcolepsy in most mammals, including humans, and these individuals exhibit an abnormal GH secretion profile characterized by elevated GH levels during daylight hours and reduced levels at night [48, 49]

Differential regulatory mechanism of Ca 2+ /calmodulin-dependent protein kinase kinase isoforms

Taking all of these findings into account, the inhibitory action of GSH on melanogenesis is evident