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Quality and relevance assessment Study relevance: Each source was evaluated for its relevance to the key themes of the review

Firstly, activated mTOR reduces the antioxidant activity of mesangial cells in the glomerulus, promoting the production of ROS

Community reports on CJC + ipa for bulking cluster around three themes: deeper sleep within the first week, fuller-looking muscles around weeks 3-4, and a 3-5 lb lean-mass gain on a 300-500 kcal surplus across a full 16-week cycle

Imaging was performed using the Axio Observer 7 (Zeiss, Germany), and quantification was done with ImageJ (National Institutes of Health, USA, version 2.3.0)