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[1] Beyond neurotrophins, Semax has been reported to modulate monoaminergic systems, raising striatal serotonin-metabolite levels and potentiating amphetamine-evoked dopamine release in rodent brain

Lin JR, Izar B, Wang S, et al

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Its popularity comes from the dual-pathway mechanism: CJC-1295 provides the GHRH signal, and Ipamorelin amplifies each pulse through the ghrelin receptor