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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

In animal and emerging human data, it upregulates VEGF (vascular endothelial growth factor) and FGF (fibroblast growth factor) to spark angiogenesis the creation of new blood vessels critical for healing

These range from acute treatments for heart failure to chronic management of hypertension and related conditions

In some embodiments, the otic pharmaceutical formulation comprises about 66% by weight of the triglycerides