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Future studies should prioritize large-scale, single-strain multicenter RCTs to validate long-term efficacy and safety, standardize detection protocols and experimental designs to reduce heterogeneity, and deepen mechanistic exploration of Clostridium /metabolitetarget cell interactions

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Compared to classical gastroprotective peptides such as sucralfate or proton pump inhibitors (PPIs), it acts via a completely different pathway: restoration of mucosal microcirculation rather than acid reduction or formation of a mechanical protective layer