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However, even a 50% reduction in worm burden would decrease the human health problems caused by schistosomiasis, and a combination of auranofin (or another TGR inhibitor) with an agent that works by a different mechanism might be more effective and would also reduce the chances of the parasite developing drug resistance

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The use of a second medicine, if necessary, or switching to a different drug are the next steps after monotherapy in an effort to determine the best therapy for each patient

The absence of a viral culture and animal model system for EEHV and a limited toolbox for the elephant immune system relative to other animal species has hampered progress in antiviral drug and vaccine development