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Clinically, the concept of cold acclimation may provide a useful framework for understanding the vulnerability of distal hypothermic tissuessuch as the hands, feet, and nasal mucosain cold environments, as well as the increased risk of infection associated with therapeutic hypothermia

Gut bacteria produce metabolites that can bind to DNA and influence the expression of genes regulating nutrient intake and metabolism

4,5 Diabetic peripheral neuropathy (DPN), the most common form of DN, is characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction in the extremities and is a primary cause of foot ulcers and lower-limb amputations in diabetes patients

Molecular Pharmacology, 88 (2), 291-303