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To guarantee the energy production of hepatocytes from OXPHOS, p53 exerts its pleiotropic role in limiting glycolysis and diverting pyruvate toward the tricarboxylic acid cycle (TCA) 30

At the end of your esophagus is your lower esophageal sphincter (LES), a ring of muscles that controls the flow of food between your esophagus and stomach

In March 2026, FDA released the Flavored Electronic Nicotine Delivery Systems (ENDS) Premarket Applications Considerations Related to Youth Risk

In vivo and in vitro studies on nicotine exposure demonstrated the activation of several downstream signaling pathways in fibroblast and airway epithelial cells [80, 81]