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YC-1, an early identified HIF inhibitor, operates by diminishing the expression of HIF-1 target genes, including VEGF and inducible nitric oxide synthase (iNOS), through suppression of HIF-1 stability and transcriptional activity under hypoxic conditions, thereby modulating inflammatory responses and vascularization in RA (211)

As a precursor for GSH synthesis, adjuvant therapy with NAC could resolve SARS-CoV-2-induced OxS via GSH release and help restore cellular redox homeostasis during COVID-19 and PASC 605

Cadmium monitoring at the workplace: effectiveness of a combination of air- and biomonitoring

Its only controlled human trial a Phase II study for postoperative ileus failed its primary endpoint , and clinical development was discontinued [5]