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Manufacturers had until May to submit marketing applications to FDA, and if the products didnt get authorization by July, the products were supposed to be considered illegal and removed from the market

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However, some of this science is less well-established, especially when it comes to questions of clinical relevance to humans under realistic use conditions involving long-term and exclusive use of non-combustible products: Chemistry and toxicology studies show that some types of harmful emissions can be detected in heated tobacco products and e-cigarettes

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