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The United States and Australia were the countries or regions that received the most funding and conducted extensive research on smoking cessation (Supplementary file Figure 1)

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In the present study, except BA synthase FXR, CYP7A1 and CYP7B1 and efflux transporters NTCP and organic solute transporter (OST), nicotine did not change the expression of the efflux transporter BSEP, OATP1, OST, MRP2/3/4 and alternative pathway synthase cytochrome P450 Family 27 Subfamily A Member 1 (CYP27A1) and CYP8B1

Eng Es It Sp Nicotine use and exposure to secondhand smoke together represent the number one cause of preventable deaths in this country