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found that signal transducers and activators of transcription 3 (STAT3) promote MYC expression in tumor cells in AML, which in turn regulates the transcription of amino acid transporter SLC1A5, promotes Gln metabolism in AML cells, and oxidative phosphorylation (OXPHOS) of leukemia stem cells (LSCs)

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Bioenergetic profiling The real-time OCR was measured using a Seahorse Mini HS XF instrument (Agilent)

As a redox-active cofactor, BH4 directly scavenges PL-OOHs and indirectly promotes CoQ10 biosynthesis, thus conferring resistance to ferroptosis (Du et al., 2024)