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An approximate similarity of the topography of the bilirubin deposition to that of kernicterus was reported in the initial work, but the critical question concerning whether the brain bilirubin deposition was followed by neuronal injury was not answered

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For example, after oral administration of microcapsules containing Escherichia coli DH5 with urease-producing ability in uremic rats, the serum urea level decreased significantly (203)