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Together, these data suggest that BDHI is a mildly reactive electrophile that can acts as a covalent protein modifier upon interaction within protein binding pockets and its proteomic reactivity and selectivity can be largely modulated by fragments appended to the warhead

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Multiomics confirm mitochondrial adaptations in response to SHP2/MEK inhibition To investigate the underlying properties of the screening response of our cell lines, we performed metabolomic, proteomic, and transcriptomic analyses