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An injection bypasses that route

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Moreover IL-12 amplifies both growth rates and cytotoxic activities among NK cells alongside CD4+ and CD8+ T lymphocytes, resulting in increased production of perforin and granzyme B, which are key molecules essential for CTLs capacity to eradicate tumor cells (74, 75)

This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging