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You should avoid this combination if you: Have liver disease or take medications processed by CYP450 enzymes Are pregnant, breastfeeding, or under 18 safety data is lacking Have a sensitive digestive system and dont tolerate GI side effects well Already take metformin or other insulin-sensitizing drugs, as stacking may be redundant or risky If any of these apply to you, consult a healthcare provider before adding berberine or consider safer, more studied alternatives
British Journal of Sports Medicine 44(10):725-730
Additionally, the composite also doesnt exhibit structural and phenotypic anomalies, apoptosis, or gut necrosis, indicating that they are safe to be used in biomedical and environmental applications [193]
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