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The accumulation of cotinine or nicotine in the FF or ovarian tissue in smoking patients undergoing MAR treatment has been reported 8,25,38,39,40,41,42

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Studies carried out with smokers have confirmed these findings in animal models, showing alterations in the respiratory epithelium as an enlargement of the naked epithelium,25 a greater prevalence of hyperplasia and cell atypias26 and ultrastructural cilia abnormalities27