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Harrell MB, Weaver SR, Loukas A, Creamer M, Marti CN, Jackson CD, et al

[21] Behavioral counseling and medications each increase the rate of successfully quitting smoking, and a combination of behavioral counseling with a medication such as bupropion is more effective than either intervention alone

economy about $100 billion per year, including direct medical costs and the indirect cost of lost productivity from employee sick time due to smoking-related illness