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The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury

In our study we observed that deletion of these genes shows sensitivity to 5-OP on plate (Fig S5) but the exact mechanisms would need further exploration

The major difference is that whereas only the main chain carboxylate of wild-type Thr1273 interacts with basic Lys17 on the WD40 surface, both the side chain and main chain carboxylate groups of the clientized Glu1273 residue form extensive interactions with a WD40 basic cluster of Arg15, Lys17, and Arg272 (Fig

Skepticism, of course, is the lifeblood of scientific progress, and several experts not involved in the study have urged caution