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The honest caveat worth repeating is that the science on glutathione for skin brightening is still developing, and high-dose, unsupervised use is not a good idea, which is the whole reason to have it done in a medical setting rather than chasing it elsewhere

Key Takeaways SkinPen microneedling can help improve the look of melasma, hyperpigmentation, and uneven skin tone over time

However, the rate of improvement slowed the largest changes occurred between weeks 4-8, with weeks 8-12 representing diminishing marginal gains

So when taken orally or topically, glutathione has its own effect in fighting its radicals, so that dark spots and blemishes appear