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BDNF plays an important role in promoting neuronal survival and synaptic plasticity and well-studied as a biomarker of illness activity in BD (Kuipers and Bramham, 2006)

Notably, in comparative assays measuring neurotrophic activity, Dihexa exhibited potency seven orders of magnitude greater than brain-derived neurotrophic factor (BDNF) in promoting new neuronal connections

Navitoclax (ABT-263), another inhibitor of the BCL-2 family members, has also been used in many different studies over the years for its ability to eliminate senescent cells by inducing apoptosis