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The two oxygen atoms of the hydroxyphosphinyl group of 43 are interacting with the zinc ion whilst hydrogen bonds with Glu371 and Tyr455 essential for catalysis are created

10.3831/KPI.2020.23.008 263 ShiP.XieS.YangJ.ZhangY.HanS.SuS.et al (2022)

Low serotonin levels can result in sadness, lack of motivation, or even depressive symptoms

This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway