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Genotyping of Slc25a39 E12.5 embryos from heterozygous mating

A meta-organismal pathway was elucidated involving gut microbiotadependent formation of TMA and host hepatic flavin monooxygenase 3dependent (FMO3-dependent) formation of TMAN-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks

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Activation of NOX enzymes in Kupffer and hepatic stellate cells induces ROS generation, thereby promoting liver fibrosis and hepatocarcinogenesis 93,94,95,96