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The most common side effect of B12 injections is irritation at the injection site, and injections are typically administered intramuscularly or subcutaneously. Less common side effects may include headache, nausea, diarrhea, itching, or a brief feeling of lightheadedness after the injection

Another class of gastric acid inhibitors known as histamine 2 (H 2 )-receptor antagonists (e.g., cimetidine, famotidine, and ranitidine), often used to treat peptic ulcer disease, has also been found to decrease the absorption of vitamin B 12 from food

Moreover, microsomal metabolism studies demonstrated that Dihexa had very low phase I metabolism, with an average intrinsic clearance of 2.72 l/min/mg and a half-life of 509.4 minutes

10.7324/JAPS.2017.70823 71 El-HanounA.El-KomyA.El-SabroutK.AbdellaM