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Compared to endogenous receptor ligands, retatrutide exhibits a stronger affinity for the GIP receptor than for the glucagon and GLP-1 receptors [112]

These molecular alterations compromise cell integrity and cellular function, impairing cellular signalling, reducing growth factor responsiveness, and increasing cell death

For normally distributed data a mixed linear model (MLM) was used, (as laid out by IBM in their SPSS Statistics guidelines, with mice IDs as subject variable and random effects, sex and APOE genotypes as factors, and age as a covariate