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In work predominantly based on animal models, certain symbiotic microorganisms have been shown to initiate gut inflammation and pathology when colonizing a genetically susceptible host (e.g., Helicobacter and segmented filamentous bacteria)

Stracke H, Hammes HP, Werkmann D, Mavrakis K, Bitsch I, Netzel M, Geyer J, Kopcke W, Sauerland C, Bretzel RG, et al: Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats

B12 can be given, orally, or through intramuscular injections

Topical vitamin C is a powerful antioxidant essential for wound healing and cell turnover