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The combined action of GLP-1 and GIP also produces more favorable effects on body composition

The reaction mixture (1.0 ml) contained 500 l of 0.2 M potassium phosphate buffer (pH 7.0) containing 2 mM EDTA, 50 l of 2 mM NADPH (prepared in 10 mM Tris HCl pH 7.0), 50 l of 20 mM GSSG, 350 l distilled water

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( In neuronal cells, SIN markedly enhances the production of antioxidant enzymes like HO-1 and SOD, affecting both protein and mRNA levels, thereby triggering the Nrf2 pathway ( 5.4 Pharmacological effects of SIN in other diseases SIN has exhibited therapeutic efficacy in various diseases, including colitis ( and IL-6 and upregulating anti-inflammatory factors, SIN has anti-inflammatory actions that greatly improve experimental colitis ( In a CCI rat model, SIN exerts dose-dependent analgesic effects, significantly alleviating heat hyperalgesia and mechanical allodynia by increasing withdrawal reflex latency and elevating pain thresholds ( , IL-1, IL-6) and downregulation of RIP3, phosphorylated JNK, and c-Fos in the spinal cord, as well as an increased number of surviving neurons in the dorsal horn, indicating attenuation of CCI-induced neuronal death ( Beyond its role in inflammation and cancer, SIN also shows potential therapeutic efficacy in diseases such as diabetes, endotoxemia, asthma, cough, and depression