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Approximately 30% of the patients with DRESS syndrome develop complications, including infections, and inflammatory and autoimmune diseases.16,28,29 Although the contribution of the Herpesviridae family to the pathogenesis of DRESS is not yet definitive, viral reactivation can occur in the absence of immunosuppressive therapies and the emergence of virus-specific CD8+ T lymphocytes suggests that herpes virus reactivation is an integral component of the DRESS pathogenic process

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This is a question that I myself have spent many a cold, New Hampshire night pondering, and in my pondering I have hypothesized a few possible contributing factors