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Repriming testing characterizes how many actuations are needed to restore consistent dosing after a defined period of non-use this reflects the real-world scenario where a patient puts down the inhaler for several days or weeks

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Rapamycin exerts anti-ferroptotic effects by decreasing transferrin receptor expression, reducing cellular iron content, and activating the iron-regulated protein-1/2 (Irp1/2) system, potentially compensating for transferrin downregulation to maintain iron homeostasis (69)

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