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Despite some controversies, such as drug concentration and timing, inconsistent conclusions due to different definitional parameters, and insufficient research on the mechanism of influence, these findings can help clinicians choose the most appropriate treatment plan and clinical follow-up

However, other known regulators of GLUT1 membrane trafficking, such as Sorting Nexin 27 (SNX27) 38 and TBC1 domain family member 5 (TBC1D5) 37 , exhibited insignificant changes after metformin treatment (Fig

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The expression level appeared to be higher in mature leaves than in immature leaves, suggesting its growth-stage specific expression (Park et al., 2004)