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1) and GK may play a central role in the alternative pathway

demonstrated that in dendritic cells (DCs), LPS-induced glycolysis is repurposed to replenish citrate, an intermediate metabolite in the TCA cycle that is depleted for the de novo synthesis of fatty acids ( 2 ( de novo lipogenesis is important for phagocytosis as it requires ongoing lipid synthesis in the ER for membrane expansion, such that Ms can surround and capture targeted pathogens for internalization ( de novo lipogenesis, an anabolic process that is NADPH-dependent, in regulating the inflammatory response of myeloid cells

doi: 10.1016/j.pt.2020.12.007 [DOI] [PubMed] [Google Scholar] 359

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