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Some of these mechanisms focus on producing reactive oxygen species, glutathione depletion, plasmid curing inhibition, efflux pump inhibition, and resistance enzyme inhibition 46,47

Restoration of DJ-1 expression ameliorates these defects by enhancing mitochondrial electron transport chain activity and reducing ROS overproduction, thereby attenuating oxidative stress-mediated neuronal damage (McCoy and Cookson, 2011)