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In fact, the loss of zinc from SOD1 results in the remaining copper in SOD1 becoming extremely toxic to motor neurons (Trumbull 2009)

The only downside is its limited capacity

Collectively, these studies suggest that enhanced glutamate export and NADPH investment in cancer cells upregulate SLC7A11 levels and enhance dependency on glucose and/or glutamine, though this may be cell line and context dependent ( Figure 2 )