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Although Roche discontinued the brand-name Accutane in 2009 due to declining market share, generic versions of Isotretinoin are still commonly prescribed today, underscoring that Isotretinoin has been used to treat acne for over 43 years

Marei HE (2022) Multimodal targeting of glioma with functionalized nanoparticles

Whartons Jelly, derived from umbilical cord tissue, is a regenerative matrix rich in growth factors, hyaluronic acid, cytokines, and extracellular matrix components

The cAMP-mediated PKA pathway has been shown to promote tumor cell proliferation and progression also in multiple preclinical cancer models [18]