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Deg-AZM had a higher liver extraction rate in monkey liver microsome, a moderate liver extraction rate in rat and human liver microsomes, and a lower liver extraction rate in mouse and dog liver microsomes, indicating that Deg-AZM was metabolized and eliminated most rapidly in monkey liver microsomes, while it exhibited a similar metabolic elimination profile in rat and human liver microsomes

Zhu D, Shen Z, Liu J, Chen J, Liu Y, Hu C, Li Z, Li Y

It is thought that a small percentage of cyanocobalamin degrades to hydroxocobalamin during storage

Mounjaro is already licensed and available in the UK for suitable patients